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Titel:

Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hoellein, A; Pickhard, A; von Keitz, F; Schoeffmann, S; Piontek, G; Rudelius, M; Baumgart, A; Wagenpfeil, S; Peschel, C; Dechow, T; Bier, H; Keller, U
Abstract:
Squamous cell cancer of the head and neck (SCCHN) is the sixth leading cause for cancer deaths worldwide. Despite extense knowledge of risk factors and pathogenesis about 50 percent of all patients and essentially every patient with metastatic SCCHN eventually die from this disease. We analyzed the clinical data and performed immunohistochemistry for Epidermal growth factor receptor (EGFR) and Aurora kinase A (Aurora-A) expression in 180 SCCHN patients. Patients characterized by elevated EGFR an...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2011
Band / Volume:
2
Heft / Issue:
8
Seitenangaben Beitrag:
599-609
Sprache:
eng
Volltext / DOI:
doi:10.18632/oncotarget.311
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21865609
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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