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Title:

Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.

Document type:
Journal Article
Author(s):
Brücher, BL; Geddert, H; Langner, C; Höfler, H; Fink, U; Siewert, JR; Sarbia, M
Abstract:
Small bowel adenocarcinoma (SB-AC) is a very rare tumor entity. Epigenetic alterations, including hypermethylation of DNA mismatch repair genes and tumor suppressor genes, seem to be important for carcinogenesis in tumors of the gastrointestinal tract, but have not yet been investigated in SB-AC. In the current study, the prevalence of hypermethylation in a panel of genes involved in gastrointestinal carcinogenesis (hMLH1, HPP1, p14(ARF), p16(INK4A), APC) was determined in a series of SB-AC. Par...     »
Journal title abbreviation:
Int J Cancer
Year:
2006
Journal volume:
119
Journal issue:
6
Pages contribution:
1298-302
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.21990
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16619216
Print-ISSN:
0020-7136
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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