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Title:

Promotion of haematopoietic activity in embryonic stem cells by the aorta-gonad-mesonephros microenvironment.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Krassowska, A; Gordon-Keylock, S; Samuel, K; Gilchrist, D; Dzierzak, E; Oostendorp, R; Forrester, LM; Ansell, JD
Abstract:
We investigated whether the in vitro differentiation of ES cells into haematopoietic progenitors could be enhanced by exposure to the aorta-gonadal-mesonephros (AGM) microenvironment that is involved in the generation of haematopoietic stem cells (HSC) during embryonic development. We established a co-culture system that combines the requirements for primary organ culture and differentiating ES cells and showed that exposure of differentiating ES cells to the primary AGM region results in a sign...     »
Journal title abbreviation:
Exp Cell Res
Year:
2006
Journal volume:
312
Journal issue:
18
Pages contribution:
3595-603
Language:
eng
Fulltext / DOI:
doi:10.1016/j.yexcr.2006.08.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16952354
Print-ISSN:
0014-4827
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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