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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Sommermeyer, D; Neudorfer, J; Weinhold, M; Leisegang, M; Engels, B; Noessner, E; Heemskerk, MH; Charo, J; Schendel, DJ; Blankenstein, T; Bernhard, H; Uckert, W
Title:
Designer T cells by T cell receptor replacement.
Abstract:
T cell receptor (TCR) gene transfer is a convenient method to produce antigen-specific T cells for adoptive therapy. However, the expression of two TCR in T cells could impair their function or cause unwanted effects by mixed TCR heterodimers. With five different TCR and four different T cells, either mouse or human, we show that some TCR are strong--in terms of cell surface expression--and replace weak TCR on the cell surface, resulting in exchange of antigen specificity. Two strong TCR are co-...     »
Journal title abbreviation:
Eur J Immunol
Year:
2006
Journal volume:
36
Journal issue:
11
Pages contribution:
3052-9
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200636539
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17051621
Print-ISSN:
0014-2980
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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