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Title:

Pyridone 6, a pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

Document type:
Journal Article
Author(s):
Pedranzini, L; Dechow, T; Berishaj, M; Comenzo, R; Zhou, P; Azare, J; Bornmann, W; Bromberg, J
Abstract:
Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived cell lines. P6 induced growth arrest and subsequent apoptosis of the IL-6-dependent hybridoma and myeloma-derived cell lines (B9 and INA-6) grown either in IL-6-containing medium or...     »
Journal title abbreviation:
Cancer Res
Year:
2006
Journal volume:
66
Journal issue:
19
Pages contribution:
9714-21
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-05-4280
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17018630
Print-ISSN:
0008-5472
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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