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Title:

5'-Triphosphate RNA is the ligand for RIG-I.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hornung, Veit; Ellegast, Jana; Kim, Sarah; Brzózka, Krzysztof; Jung, Andreas; Kato, Hiroki; Poeck, Hendrik; Akira, Shizuo; Conzelmann, Karl-Klaus; Schlee, Martin; Endres, Stefan; Hartmann, Gunther
Abstract:
The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is largely unknown. We demonstrated that the 5'-triphosphate end of RNA generated by viral polymerases is responsible for retinoic acid-inducible protein I (RIG-I)-mediated detection of RNA molecules. Detection of 5'-triphosphate RNA is abrogated by capping of the 5'-triphosphate end or by nucleoside modification of RNA, both occurring during posttranscriptional RNA processing...     »
Journal title abbreviation:
Science
Year:
2006
Journal volume:
314
Journal issue:
5801
Pages contribution:
994-7
Language:
eng
Fulltext / DOI:
doi:10.1126/science.1132505
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17038590
Print-ISSN:
0036-8075
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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