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Titel:

Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial.

Dokumenttyp:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Teipel, SJ; Drzezga, A; Bartenstein, P; Möller, HJ; Schwaiger, M; Hampel, H
Abstract:
RATIONALE: Cholinergic enhancement is among the best established treatments of Alzheimer's disease (AD). The cognitive effects of treatment are thought to be mediated by improvement of neuronal transmission. Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) by measuring cortical metabolic response to activation assesses integrity of neuronal transmission in vivo. OBJECTIVE: To determine the effects of treatment with donepezil, a centrally selective acetylcholinesterase inhibito...     »
Zeitschriftentitel:
Psychopharmacology (Berl)
Jahr:
2006
Band / Volume:
187
Heft / Issue:
1
Seitenangaben Beitrag:
86-94
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00213-006-0408-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16767418
Print-ISSN:
0033-3158
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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