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Title:

Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial.

Document type:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Author(s):
Mertens, P; Maes, A; Nuyts, J; Belmans, A; Desmet, W; Esplugas, E; Charlier, F; Figueras, J; Sambuceti, G; Schwaiger, M; Mortelmans, L; Van de Werf, F
Abstract:
BACKGROUND: Inflammatory responses induced by reperfusion of previously ischemic myocardial tissue may lead to further damage of the microvascular structures. A group of cell adhesion molecules, named selectins, initiate those inflammatory changes at the endothelial wall surface. Recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig), a P-selectin antagonist, was shown to have beneficial effects in several animal models of acute myocardial ischemia. We performed a mechanistic study...     »
Journal title abbreviation:
Am Heart J
Year:
2006
Journal volume:
152
Journal issue:
1
Pages contribution:
125.e1-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ahj.2006.04.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16824841
Print-ISSN:
0002-8703
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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