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Title:

Synthesis and evaluation of a radiometal-labeled macrocyclic chelator-derivatised thymidine analog.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schmid, M; Neumaier, B; Vogg, AT; Wczasek, K; Friesen, C; Mottaghy, FM; Buck, AK; Reske, SN
Abstract:
Several radiolabeled thymidine analogs as metabolic probes of cell proliferation were developed specifically addressing DNA synthesis. Thymidine analogs containing carboranylalkyl groups for neutron capture therapy at the N-3 position were found to be good substrates for cytosolic thymidine kinase 1 (TK1). According to this approach, a DO3A macrocycle in N-3 position was attached to thymidine. The 3-DO3A thymidine analog was labeled with 68Ga and 111In. Different lipophilicities of the correspon...     »
Journal title abbreviation:
Nucl Med Biol
Year:
2006
Journal volume:
33
Journal issue:
3
Pages contribution:
359-66
Language:
eng
Fulltext / DOI:
doi:10.1016/j.nucmedbio.2005.12.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16631084
Print-ISSN:
0969-8051
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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