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Title:

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

Document type:
Journal Article
Author(s):
Janssen, KP; Vignjevic, D; Boisgard, R; Falguières, T; Bousquet, G; Decaudin, D; Dolle, F; Louvard, D; Tavitian, B; Robine, S; Johannes, L
Abstract:
Efficient methods for tumor targeting are eagerly awaited and must satisfy several challenges: molecular specificity, transport through physiologic barriers, and capacity to withstand extracellular or intracellular degradation and inactivation by the immune system. Through interaction with its hosts, the intestinal pathogen-produced Shiga toxin has evolved molecular properties that are of interest in this context. Its nontoxic B-subunit binds to the cellular toxin receptor, glycosphingolipid Gb3...     »
Journal title abbreviation:
Cancer Res
Year:
2006
Journal volume:
66
Journal issue:
14
Pages contribution:
7230-6
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-06-0631
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16849571
Print-ISSN:
0008-5472
TUM Institution:
Chirurgische Klinik und Poliklinik
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