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Title:

Non-invasive imaging of glycoprotein VI binding to injured arterial lesions.

Document type:
Journal Article; Article
Author(s):
Gawaz, M; Konrad, I; Hauser, AI; Sauer, S; Li, Z; Wester, HJ; Bengel, FM; Schwaiger, M; Schömig, A; Massberg, S; Haubner, R
Abstract:
Glycoprotein VI (GPVI) is the major platelet collagen receptor and plays a critical role in the process of thrombosis at sites of atherosclerotic lesions. This study evaluates the feasibility of radiolabeled soluble GPVI to identify injured arterial lesions. Radiolabeling was carried out using the iodogen method and resulted in the radioiodinated GPVI in radiochemical yields between 97-100%. The biodistribution of [(125)I]GPVI was determined in normal mice and demonstrated a blood clearance half...     »
Journal title abbreviation:
Thromb Haemost
Year:
2005
Journal volume:
93
Journal issue:
5
Pages contribution:
910-3
Language:
eng
Fulltext / DOI:
doi:10.1267/THRO05050910
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15886808
Print-ISSN:
0340-6245
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik und Poliklinik für Nuklearmedizin
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