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Title:

Preparation and preclinical assessment of folate-conjugated, radiolabelled antibodies

Document type:
Journal Article; Article
Author(s):
Henriksen, G; Bruland, OS; Larsen, RH
Abstract:
Background: The folate receptor (FR) is frequently over-expressed on human cancer cells and may be a suitable target for radiopharmaceuticals. Because of FR expression in the kidneys, the rapidly renal clearing folate is not well suited as a carrier for therapeutic radionuclides. As an alternative, folate-immunoglobulin conjugates were studied as potential carriers for radionuclides. Materials and Methods: Two types of conjugate were evaluated: (i) folate conjugated to osteosarcoma antigen direc...     »
Journal title abbreviation:
Anticancer Res
Year:
2005
Journal volume:
25
Journal issue:
1A
Pages contribution:
9-15
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15816513
Print-ISSN:
0250-7005
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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