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Titel:

Noninvasive visualization of the activated alpha v beta 3 integrin in cancer patients by positron emission tomography and [F-18]Galacto-RGD

Dokumenttyp:
Journal Article; Article
Autor(en):
Haubner, R; Weber, WA; Beer, AJ; Vabuliene, E; Reim, D; Sarbia, M; Becker, KF; Goebel, M; Hein, R; Wester, HJ; Kessler, H; Schwaiger, M
Abstract:
Background The integrin alpha v beta 3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches. Several techniques are being studied to enable noninvasive determination of alpha v beta 3 expression. We developed [F-18]Galacto-RGD, a F-18-labeled glycosylated alpha v beta 3 antagonist, allowing monitoring of alpha v beta 3 expression with positron emission tomography (PET). Methods and Findings Here we show by...     »
Zeitschriftentitel:
PLoS Med
Jahr:
2005
Band / Volume:
2
Heft / Issue:
3
Seitenangaben Beitrag:
244-252
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15783258
Print-ISSN:
1549-1277
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Dermatologie und Allergologie; Klinik und Poliklinik für Nuklearmedizin
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