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Title:

Mouse models of K-ras-initiated carcinogenesis.

Document type:
Journal Article; Review
Author(s):
Janssen, KP; Abal, M; Abala, M; El Marjou, F; Louvard, D; Robine, S
Abstract:
Activating mutations of the oncogene K-ras are found in one third of all human cancers. Much of our knowledge on K-ras signal transduction and its influence on tumor initiation and progression comes from in vitro studies with cell lines. However, mouse models of human cancer allow a much more faithful recapitulation of the human disease, and the in vivo perspective is crucial for our understanding of neoplasia. In recent years, several new murine models for K-ras-induced tumorigenesis have been...     »
Journal title abbreviation:
Biochim Biophys Acta
Year:
2005
Journal volume:
1756
Journal issue:
2
Pages contribution:
145-54
Language:
eng
Fulltext / DOI:
doi:10.1016/j.bbcan.2005.07.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16126346
Print-ISSN:
0006-3002
TUM Institution:
Chirurgische Klinik und Poliklinik
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