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Title:

CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model.

Document type:
Journal Article
Author(s):
Hüser, N; Tertilt, C; Gerauer, K; Maier, S; Traeger, T; Assfalg, V; Reiter, R; Heidecke, CD; Pfeffer, K
Abstract:
Chronic graft rejection mediated by cellular immune responses still poses a serious clinical problem in transplant surgery. Chemokines coordinate the recruitment of leukocytes in inflammatory and immune responses. Their precise functions in the rejection of allografts are still ill defined. This study investigates the role of chemokine receptor 4 (CCR4) in acute and chronic cardiac allograft rejection in mice. Allogeneic hearts were transplanted into CCR4 deficient (CCR4(-/-)) and control recipi...     »
Journal title abbreviation:
Eur J Immunol
Year:
2005
Journal volume:
35
Journal issue:
1
Pages contribution:
128-38
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200324745
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15593118
Print-ISSN:
0014-2980
TUM Institution:
Chirurgische Klinik und Poliklinik
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