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Title:

The mutagenic potential of duodenoesophageal reflux.

Document type:
Journal Article
Author(s):
Theisen, J; Peters, JH; Fein, M; Hughes, M; Hagen, JA; Demeester, SR; Demeester, TR; Laird, PW
Abstract:
SUMMARY BACKGROUND DATA: Duodenogastric-esophageal reflux disease is directly linked to Barrett's esophagus and to the development of esophageal adenocarcinoma. Despite this link, little is known about the mutagenic potential of refluxed material on the esophageal mucosa. We hypothesize that the reflux of gastric and duodenal content causes mutations in esophageal mucosa in vivo. METHODS: Seven Sprague Dawley/Big Blue F1 lacI transgenic rats underwent esophagoduodenostomy (ED) to surgically crea...     »
Journal title abbreviation:
Ann Surg
Year:
2005
Journal volume:
241
Journal issue:
1
Pages contribution:
63-8
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15621992
Print-ISSN:
0003-4932
TUM Institution:
Chirurgische Klinik und Poliklinik
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