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Title:

Microsatellite instability of selective target genes in HNPCC-associated colon adenomas.

Document type:
Journal Article
Author(s):
Woerner, SM; Kloor, M; Mueller, A; Rueschoff, J; Friedrichs, N; Buettner, R; Buzello, M; Kienle, P; Knaebel, HP; Kunstmann, E; Pagenstecher, C; Schackert, HK; Möslein, G; Vogelsang, H; von Knebel Doeberitz, M; Gebert, JF
Abstract:
Microsatellite instability (MSI) occurs in most hereditary nonpolyposis colorectal cancers (HNPCC) and less frequently in sporadic tumors as the result of DNA mismatch repair (MMR) deficiency. Instability at coding microsatellites (cMS) in specific target genes causes frameshift mutations and functional inactivation of affected proteins, thereby providing a selective growth advantage to MMR deficient cells. At present, little is known about Selective Target Gene frameshift mutations in preneopla...     »
Journal title abbreviation:
Oncogene
Year:
2005
Journal volume:
24
Journal issue:
15
Pages contribution:
2525-35
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.onc.1208456
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15735733
Print-ISSN:
0950-9232
TUM Institution:
Chirurgische Klinik und Poliklinik
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