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Titel:

Microsatellite instability of selective target genes in HNPCC-associated colon adenomas.

Dokumenttyp:
Journal Article
Autor(en):
Woerner, SM; Kloor, M; Mueller, A; Rueschoff, J; Friedrichs, N; Buettner, R; Buzello, M; Kienle, P; Knaebel, HP; Kunstmann, E; Pagenstecher, C; Schackert, HK; Möslein, G; Vogelsang, H; von Knebel Doeberitz, M; Gebert, JF
Abstract:
Microsatellite instability (MSI) occurs in most hereditary nonpolyposis colorectal cancers (HNPCC) and less frequently in sporadic tumors as the result of DNA mismatch repair (MMR) deficiency. Instability at coding microsatellites (cMS) in specific target genes causes frameshift mutations and functional inactivation of affected proteins, thereby providing a selective growth advantage to MMR deficient cells. At present, little is known about Selective Target Gene frameshift mutations in preneopla...     »
Zeitschriftentitel:
Oncogene
Jahr:
2005
Band / Volume:
24
Heft / Issue:
15
Seitenangaben Beitrag:
2525-35
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1208456
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15735733
Print-ISSN:
0950-9232
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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