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Titel:

The mutagenic potential of duodenoesophageal reflux.

Dokumenttyp:
Journal Article
Autor(en):
Theisen, J; Peters, JH; Fein, M; Hughes, M; Hagen, JA; Demeester, SR; Demeester, TR; Laird, PW
Abstract:
SUMMARY BACKGROUND DATA: Duodenogastric-esophageal reflux disease is directly linked to Barrett's esophagus and to the development of esophageal adenocarcinoma. Despite this link, little is known about the mutagenic potential of refluxed material on the esophageal mucosa. We hypothesize that the reflux of gastric and duodenal content causes mutations in esophageal mucosa in vivo. METHODS: Seven Sprague Dawley/Big Blue F1 lacI transgenic rats underwent esophagoduodenostomy (ED) to surgically crea...     »
Zeitschriftentitel:
Ann Surg
Jahr:
2005
Band / Volume:
241
Heft / Issue:
1
Seitenangaben Beitrag:
63-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15621992
Print-ISSN:
0003-4932
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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