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Titel:

Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy.

Dokumenttyp:
Journal Article; Article
Autor(en):
Holm, PS; Lage, H; Bergmann, S; Jürchott, K; Glockzin, G; Bernshausen, A; Mantwill, K; Ladhoff, A; Wichert, A; Mymryk, JS; Ritter, T; Dietel, M; Gansbacher, B; Royer, HD
Abstract:
Resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression of the P-glycoprotein gene mdr1, which plays a major role in the development of a multidrug resistant-tumor phenotype. YB-1 predicts drug resistance and patient outcome in breast cancer. Thus, YB-1 is a promising target for new therapeutic approaches to defeat multidrug resistance. In drug-resistant cancer cells and...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2004
Band / Volume:
64
Heft / Issue:
1
Seitenangaben Beitrag:
322-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14729641
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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