User: Guest  Login
Less Searchfields
Simple search
Title:

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.

Document type:
Journal Article; Article
Author(s):
Elezkurtaj, S; Kopitz, C; Baker, AH; Perez-Cantó, A; Arlt, MJ; Khokha, R; Gansbacher, B; Anton, M; Brand, K; Kruger, A
Abstract:
BACKGROUND: Matrix metalloproteinases (MMPs) are critical for metastasis of tumor cells. Tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural MMP inhibitor, was shown to reduce metastasis in different models. Here, we investigated whether increased TIMP-1 levels in the liver achieved by adenoviral gene transfer will effectively inhibit liver metastasis of two independent tumor cell lines. METHOD: TIMP-1 was transferred with adenoviral vectors into the livers of DBA/2 and Balb/c mice, whi...     »
Journal title abbreviation:
J Gene Med
Year:
2004
Journal volume:
6
Journal issue:
11
Pages contribution:
1228-37
Language:
eng
Fulltext / DOI:
doi:10.1002/jgm.637
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15390257
Print-ISSN:
1099-498X
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
 BibTeX