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Titel:

The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression

Dokumenttyp:
Journal Article; Article
Autor(en):
Orelio, C; Harvey, KN; Miles, C; Oostendorp, RAJ; van der Horn, K; Dzierzak, E
Abstract:
Apoptosis is an essential process in embryonic tissue remodeling and adult tissue homeostasis. Within the adult hematopoietic system, it allows for tight regulation of hematopoietic cell subsets. Previously, it was shown that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the viability and activity of hematopoietic cells under normal and/or stressful conditions. However, a role for apoptosis in the embryonic hematopoietic system has not yet been established. Since the first hema...     »
Zeitschriftentitel:
Blood
Jahr:
2004
Band / Volume:
103
Heft / Issue:
11
Seitenangaben Beitrag:
4084-4092
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14962910
Print-ISSN:
0006-4971
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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