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Title:

Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells.

Document type:
Journal Article; Article
Author(s):
Essler, M; Linder, S; Schell, B; Hüfner, K; Wiedemann, A; Randhahn, K; Staddon, JM; Aepfelbacher, M
Abstract:
Cytotoxic necrotizing factor 1 (CNF-1) is an exotoxin of Escherichia coli that constitutively activates the GTPases Rho, Rac, and CDC42. Stimulation of Rho was shown to enhance myosin light-chain (MLC) phosphorylation via Rho kinase-mediated inhibition of MLC phosphatase in endothelial cells. Here we report that 3 h after CNF stimulation of endothelial cells, RhoA was activated and MLC phosphorylation was increased in a Rho/Rho-kinase-dependent manner, but no decrease in MLC phosphatase activity...     »
Journal title abbreviation:
Infect Immun
Year:
2003
Journal volume:
71
Journal issue:
9
Pages contribution:
5188-93
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12933863
Print-ISSN:
0019-9567
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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