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Title:

Lysophosphatidic acid is the unique platelet-activating substance in human malignant ascites.

Document type:
Journal Article; Article
Author(s):
Sandmann, G; Siess, W; Essler, M
Abstract:
Pathological blood platelet activation promotes thrombosis in cancer patients, but the specific substances involved are still under investigation. Tumor exudates have been described to contain lysophosphatidic acid (LPA), a known platelet-activating substance, and the concentration of mediators present in malignant ascites are constantly equilibrated with the concentration in plasma. We hypothesized that the ascites of cancer patients might activate platelets, and that this may be caused by LPA....     »
Journal title abbreviation:
Eur J Med Res
Year:
2003
Journal volume:
8
Journal issue:
9
Pages contribution:
397-404
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14555295
Print-ISSN:
0949-2321
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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