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Titel:

Inhibition of the proteasome induces cell cycle arrest and apoptosis in mantle cell lymphoma cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bogner, C; Ringshausen, I; Schneller, F; Fend, F; Quintanilla-Martinez, L; Häcker, G; Goetze, K; Oostendorp, R; Peschel, C; Decker, T
Abstract:
Mantle cell lymphoma (MCL) is a distinctive non-Hodgkin's lymphoma subtype, characterized by overexpression of cyclin D1 as a consequence of the chromosomal translocation t(11; 14)(q13; q32). MCL remains an incurable disease, combining the unfavourable clinical features of aggressive and indolent lymphomas. The blastic variant of MCL, which is often associated with additional cytogenetic alterations, has an even worse prognosis and new treatment options are clearly needed. The present study inve...     »
Zeitschriftentitel:
Br J Haematol
Jahr:
2003
Band / Volume:
122
Heft / Issue:
2
Seitenangaben Beitrag:
260-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12846895
Print-ISSN:
0007-1048
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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