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Titel:

Calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin B to control excessive hypertrophic signaling.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Grammer, JB; Bleiziffer, S; Monticelli, F; Lange, R; Bauernschmitt, R
Abstract:
In the compensatory state of human left ventricular hypertrophy (LVH), the remodeling processes in the extracellular matrix and the role of calcineurin (Cn) are not completely understood. The present work aimed to analyze the expression and activity of matrix metalloproteinases (MMPs), their endogenous inhibitors (TIMPs), and of Cn in patients with compensated LVH. By semiquantitative RT-PCR, Western blotting, and gelatine zymography, we determined mRNA, protein, and/or enzyme activity levels of...     »
Zeitschriftentitel:
Basic Res Cardiol
Jahr:
2006
Band / Volume:
101
Heft / Issue:
4
Seitenangaben Beitrag:
292-300
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00395-006-0598-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16688406
Print-ISSN:
0300-8428
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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