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- Title:
Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
- Author(s):
- Ma, D; Zhang, B; Hoffmann, U; Sundrup, MG; Eikermann, M; Isaacs, L
- Abstract:
- Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.
- Journal title abbreviation:
- Angew Chem Int Ed Engl
- Year:
- 2012
- Journal volume:
- 51
- Journal issue:
- 45
- Pages contribution:
- 11358-62
- Language:
- eng
- Fulltext / DOI:
- doi:10.1002/anie.201206031
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/23047893
- Print-ISSN:
- 1433-7851
- TUM Institution:
- Klinik für Anästhesiologie (DHM)
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