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Title:

Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Hoffmann, U; Sukhotinsky, I; Atalay, YB; Eikermann-Haerter, K; Ayata, C
Abstract:
Maintenance of transmembrane ionic gradients and their restoration after cortical spreading depression (CSD) are energy dependent. We recently showed an inverse relationship between blood pressure and CSD duration that is independent of tissue oxygenation. Here, we tested the alternative hypothesis that glucose availability becomes rate-limiting for CSD recovery upon reduced blood pressure in anesthetized rats under full systemic physiological monitoring. Hypotension induced by controlled exsang...     »
Journal title abbreviation:
Exp Neurol
Year:
2012
Journal volume:
238
Journal issue:
2
Pages contribution:
130-2
Language:
eng
Fulltext / DOI:
doi:10.1016/j.expneurol.2012.08.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22981452
Print-ISSN:
0014-4886
TUM Institution:
Klinik für Anästhesiologie (DHM)
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