Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.

Titel:: Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Autor(en):: Ma, D; Zhang, B; Hoffmann, U; Sundrup, MG; Eikermann, M; Isaacs, L
Abstract:: Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.
Zeitschriftentitel:: Angew Chem Int Ed Engl
Jahr:: 2012
Band / Volume:: 51
Heft / Issue:: 45
Seitenangaben Beitrag:: 11358-62
Sprache:: eng
Volltext / DOI:: doi:10.1002/anie.201206031
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/23047893
Print-ISSN:: 1433-7851
TUM Einrichtung:: Klinik für Anästhesiologie (DHM)
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