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Title:

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.

Document type:
Journal Article; Journal Article
Author(s):
Becker, K; Eder, M; Ranft, A; von Meyer, L; Zieglgänsberger, W; Kochs, E; Dodt, HU
Abstract:
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in t...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
6
Pages contribution:
e39346
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0039346
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22723999
Print-ISSN:
1932-6203
TUM Institution:
Klinik für Anästhesiologie (DHM)
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