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Titel:

Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Eikermann, M; Grosse-Sundrup, M; Zaremba, S; Henry, ME; Bittner, EA; Hoffmann, U; Chamberlin, NL
Abstract:
Procedural sedation is frequently performed in spontaneously breathing patients, but hypnotics and opioids decrease respiratory drive and place the upper airway at risk for collapse.In a randomized, controlled, cross-over, pharmaco-physiologic study in 12 rats, we conducted acute experiments to compare breathing and genioglossus electromyogram activity at equianesthetic concentrations of ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist that combines potent analgesic with hypno...     »
Zeitschriftentitel:
Anesthesiology
Jahr:
2012
Band / Volume:
116
Heft / Issue:
1
Seitenangaben Beitrag:
35-46
Sprache:
eng
Volltext / DOI:
doi:10.1097/ALN.0b013e31823d010a
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22108392
Print-ISSN:
0003-3022
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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