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Titel:

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.

Dokumenttyp:
Journal Article; Journal Article
Autor(en):
Becker, K; Eder, M; Ranft, A; von Meyer, L; Zieglgänsberger, W; Kochs, E; Dodt, HU
Abstract:
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in t...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
e39346
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0039346
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22723999
Print-ISSN:
1932-6203
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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