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Title:

Modulation of ligand-gated ion channels as a novel pharmacological principle.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Meeting Abstract
Author(s):
Nothdurfter, C; Tanasic, S; Rammes, G; Rupprecht, R
Abstract:
The present study investigated the functional antagonism of different antidepressants on 5-HT (3) receptor function and the role of lipid rafts for these modulatory effects. Electrophysiological recordings of 5-HT evoked cation currents were recorded with N1E-115 and HEK-5-HT (3A) cells and hippocampal neurons. The characterization of the antagonism of antidepressants was made by the displacement of [ (3)H]GR65630 binding. For membrane fractionation, sucrose density gradient centrifugation was u...     »
Journal title abbreviation:
Pharmacopsychiatry
Year:
2011
Journal volume:
44 Suppl 1
Pages contribution:
S27-34
Language:
eng
Fulltext / DOI:
doi:10.1055/s-0031-1271704
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21544743
Print-ISSN:
0176-3679
TUM Institution:
Klinik für Anästhesiologie (DHM)
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