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Titel:

Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Nothdurfter, C; Tanasic, S; Di Benedetto, B; Rammes, G; Wagner, EM; Kirmeier, T; Ganal, V; Kessler, JS; Rein, T; Holsboer, F; Rupprecht, R
Abstract:
Because of the biochemical colocalization of the 5-HT(3) receptor and antidepressants within raft-like domains and their antagonistic effects at this ligand-gated ion channel, we investigated the impact of lipid raft integrity for 5-HT(3) receptor function and its modulation by antidepressants. Treatment with methyl-beta-cyclodextrine (MbetaCD) markedly reduced membrane cholesterol levels and caused a more diffuse membrane distribution of the lipid raft marker protein flotillin-1 indicating lipi...     »
Zeitschriftentitel:
Neuropsychopharmacology
Jahr:
2010
Band / Volume:
35
Heft / Issue:
7
Seitenangaben Beitrag:
1510-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/npp.2010.20
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20200506
Print-ISSN:
0893-133X
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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