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Title:

Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Martinez-Coria, H; Green, KN; Billings, LM; Kitazawa, M; Albrecht, M; Rammes, G; Parsons, CG; Gupta, S; Banerjee, P; LaFerla, FM
Abstract:
Memantine is an N-methyl-d-aspartate receptor antagonist that is approved for the treatment of moderate to severe Alzheimer's disease (AD). In this study, three groups of triple-transgenic (3xTg-AD) mice with differing levels of AD-like pathology (6, 9, and 15 months of age) were treated for 3 months with doses of memantine equivalent to those used in humans. After the treatment, memantine-treated mice had restored cognition and significantly reduced the levels of insoluble amyloid-beta (Abeta),...     »
Journal title abbreviation:
Am J Pathol
Year:
2010
Journal volume:
176
Journal issue:
2
Pages contribution:
870-80
Language:
eng
Fulltext / DOI:
doi:10.2353/ajpath.2010.090452
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20042680
Print-ISSN:
0002-9440
TUM Institution:
Klinik für Anästhesiologie (DHM)
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