Anesthesia and postoperative cognitive dysfunction (POCD).
Document type:
Journal Article
Author(s):
Jungwirth, B; Zieglgänsberger, W; Kochs, E; Rammes, G
Abstract:
POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, whether its occurrence is a result of the effects of surgery or general anesthesia remains unclear. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.