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Title:

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.

Document type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Author(s):
Rupprecht, R; Rammes, G; Eser, D; Baghai, TC; Schüle, C; Nothdurfter, C; Troxler, T; Gentsch, C; Kalkman, HO; Chaperon, F; Uzunov, V; McAllister, KH; Bertaina-Anglade, V; La Rochelle, CD; Tuerck, D; Floesser, A; Kiese, B; Schumacher, M; Landgraf, R; Holsboer, F; Kucher, K
Abstract:
Most antianxiety drugs (anxiolytics) work by modulating neurotransmitters in the brain. Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is limited by the development of tolerance and withdrawal symptoms. Ligands of the translocator protein [18 kilodaltons (kD)] may promote the synthesis of endogenous neurosteroids, which also exert anxiolytic effects in animal models. Here, we found that the translocator protein (18 kD) ligand XBD173 enhanced gamma-aminobut...     »
Journal title abbreviation:
Science
Year:
2009
Journal volume:
325
Journal issue:
5939
Pages contribution:
490-3
Language:
eng
Fulltext / DOI:
doi:10.1126/science.1175055
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19541954
Print-ISSN:
0036-8075
TUM Institution:
Klinik für Anästhesiologie (DHM)
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