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Titel:

Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Vempati, S; Reindl, C; Kaza, SK; Kern, R; Malamoussi, T; Dugas, M; Mellert, G; Schnittger, S; Hiddemann, W; Spiekermann, K
Abstract:
FLT3-internal tandem duplications (FLT3-ITDs) comprise a heterogeneous group of mutations in patients with acute leukemias that are prognostically important. To characterize the mechanism of transformation by FLT3-ITDs, we sequenced the juxtamembrane region (JM) of FLT3 from 284 patients with acute leukemias. The length of FLT3-ITDs varied from 2 to 42 amino acids (AAs) with a median of 17 AAs. The analysis of duplicated AAs showed that in the majority of patients, the duplications localize betw...     »
Zeitschriftentitel:
Blood
Jahr:
2007
Band / Volume:
110
Heft / Issue:
2
Seitenangaben Beitrag:
686-94
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2006-10-053181
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17387224
Print-ISSN:
0006-4971
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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