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Titel:

C/EBP beta blocks p65 phosphorylation and thereby NF-kappa B-mediated transcription in TNF-tolerant cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zwergal, A; Quirling, M; Saugel, B; Huth, KC; Sydlik, C; Poli, V; Neumeier, D; Ziegler-Heitbrock, HW; Brand, K
Abstract:
TNF is a major mediator of inflammation, immunity, and apoptosis. Pre-exposure to TNF reduces sensitivity to restimulation, a phenomenon known as tolerance, considered as protective in sepsis, but also as a paradigm for immunoparalysis. Earlier experiments in TNF-tolerant cells display inhibition of NF-kappaB-dependent IL-8 gene expression at the transcriptional level with potential involvement of C/EBPbeta. In this study, we have shown that a kappaB motive was sufficient to mediate transcriptio...     »
Zeitschriftentitel:
J Immunol
Jahr:
2006
Band / Volume:
177
Heft / Issue:
1
Seitenangaben Beitrag:
665-72
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16785565
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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