Login
- Dokumenttyp:
- Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Henriksen, G; Spilker, ME; Sprenger, T; Hauser, AI; Platzer, S; Boecker, H; Toelle, TR; Schwaiger, M; Wester, HJ
- Titel:
- Gender dependent rate of metabolism of the opioid receptor-PET ligand [18F]fluoroethyldiprenorphine.
- Abstract:
- AIM: The morphinane-derivate 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyldiprenorphine ([(18)F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET). Correction for plasma metabolites of the arterial input function is necessary for quantitative measurements of [(18)F]FDPN binding. A study was undertaken to investigate if there are gender dependent differences in the rate of metabolism of [(18)F]FDPN. METHODS: The rate of metabolism of [(18)F]FDPN was mathematically quantified by fitting a bi-exponential function to each individual's dynamic metabolite data. RESULTS: No statistically significant gender differences were found for age, weight, body mass index or dose. However, significant differences (p < 0.01) in two of the four kinetic parameters describing the rate of metabolism were found between the two groups, with women metabolizing [(18)F]FDPN faster than men. These differences were found in the contribution of the fast and slow kinetic components of the model describing the distribution of radioactive species in plasma, indicating a higher rate of enzyme-dependent degradation of [(18)F]FDPN in women than in men. CONCLUSION: The findings reinforce the need for individualized metabolite correction during [(18)F]FDPN-PET scans and also indicate that in certain cases, grouping according to gender could be performed in order to minimize methodological errors of the input function prior to kinetic analyses.
- Zeitschriftentitel:
- Nuklearmedizin
- Jahr:
- 2006
- Band / Volume:
- 45
- Heft / Issue:
- 5
- Seitenangaben Beitrag:
- 197-200
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/17043729
- Print-ISSN:
- 0029-5566
- TUM Einrichtung:
- Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
BibTeX