Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

Titel:: Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Sprenger, T; Willoch, F; Miederer, M; Schindler, F; Valet, M; Berthele, A; Spilker, ME; Förderreuther, S; Straube, A; Stangier, I; Wester, HJ; Tölle, TR
Abstract:: Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.
Zeitschriftentitel:: Neurology
Jahr:: 2006
Band / Volume:: 66
Heft / Issue:: 7
Seitenangaben Beitrag:: 1108-10
Sprache:: eng
Volltext / DOI:: doi:10.1212/01.wnl.0000204225.15947.f8
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/16606930
Print-ISSN:: 0028-3878
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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