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Title:

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Hu, H; Jiang, C; Schuster, T; Li, GX; Daniel, PT; Lu, J
Abstract:
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in prostate cancer cells through DR4 and DR5 death receptors, but not in normal prostate cells, which do not express these receptors. Therefore, TRAIL has excellent potential to be a selective prostate cancer therapeutic agent with minimal toxic side effects. However, prostate cancer cells, as many other cancer types, develop resistance to TRAIL, and the underlying molecular mechanisms require furt...     »
Journal title abbreviation:
Mol Cancer Ther
Year:
2006
Journal volume:
5
Journal issue:
7
Pages contribution:
1873-82
Language:
eng
Fulltext / DOI:
doi:10.1158/1535-7163.MCT-06-0063
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16891474
Print-ISSN:
1535-7163
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie
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