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Title:

The effect of electroencephalogram-targeted high- and low-dose propofol infusion on histopathological damage after traumatic brain injury in the rat.

Document type:
Journal Article
Author(s):
Eberspächer, E; Heimann, K; Hollweck, R; Werner, C; Schneider, G; Engelhard, K
Abstract:
BACKGROUND: Propofol is commonly used to sedate patients after traumatic brain injury. However, the dose-dependent neuroprotective effects of propofol after head trauma are unknown. We compared histopathological damage after 6 h of electroencephalogram-targeted high- and low-dose propofol infusion in rats subjected to controlled cortical impact (CCI). METHODS: Animals were randomly assigned to CCI/propofol with electroencephalogram burst-suppression-ratio 1%-5% (CCI/lowprop), CCI/propofol with b...     »
Journal title abbreviation:
Anesth Analg
Year:
2006
Journal volume:
103
Journal issue:
6
Pages contribution:
1527-33
Language:
eng
Fulltext / DOI:
doi:10.1213/01.ane.0000247803.30582.2d
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17122234
Print-ISSN:
0003-2999
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik für Anästhesiologie (DHM)
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