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Titel:

Rate of brain atrophy in relapsing MS decreases during treatment with IFNbeta-1a.

Dokumenttyp:
Clinical Trial; Journal Article; Randomized Controlled Trial
Autor(en):
Hardmeier, M; Wagenpfeil, S; Freitag, P; Fisher, E; Rudick, RA; Kooijmans, M; Clanet, M; Radue, EW; Kappos, L
Abstract:
OBJECTIVE: To determine the time course of brain atrophy during treatment with once-weekly IM interferon beta-1a (IFNbeta-1a). METHODS: The MRI cohort (n = 386) of the European IFNbeta-1a dose comparison study in relapsing multiple sclerosis (MS) was analyzed. In addition to baseline and three annual scans, a frequent subgroup (n = 138) had two scans before treatment initiation and scans at months 4, 5, 6, 10, and 11. Brain parenchymal fraction (BPF), a normalized measure of whole-brain atrophy,...     »
Zeitschriftentitel:
Neurology
Jahr:
2005
Band / Volume:
64
Heft / Issue:
2
Seitenangaben Beitrag:
236-40
Sprache:
eng
Volltext / DOI:
doi:10.1212/01.WNL.0000149516.30155.B8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15668419
Print-ISSN:
0028-3878
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie
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