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Title:

Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rummel, C; Voss, T; Matsumura, K; Korte, S; Gerstberger, R; Roth, J; Hübschle, T
Abstract:
During systemic inflammation, cytokines are released by immune-competent cells into the circulation, which in turn signal the brain to mediate brain-controlled signs of illness. Cytokine-responsive brain cells can be mapped by histological analysis of cytokine-induced transcription factors or transcription factor-associated molecules revealing different cell phenotypes that respond to activation of the immune system. Critical sites mediating cytokine-dependent immuneffector functions can be divi...     »
Journal title abbreviation:
J Comp Neurol
Year:
2005
Journal volume:
491
Journal issue:
1
Pages contribution:
1-14
Language:
eng
Fulltext / DOI:
doi:10.1002/cne.20653
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16127698
Print-ISSN:
0021-9967
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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