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Title:

Murine TLR2 expression analysis and systemic antagonism by usage of specific monoclonal antibodies.

Document type:
Journal Article; Article
Author(s):
Meng, G; Grabiec, A; Rutz, M; Metzger, J; Luppa, PB; Wagner, H; Bauer, S; Kirschning, CJ
Abstract:
Cellular recognition of immuno-stimulatory microbial products alarming the host immune system upon infection, as well as endogenous molecular patterns representing perturbation of regular homeostasis such as through necrosis of host cells is mediated by innate pattern recognition receptors to which toll-like receptors (TLRs) belong. A variety of agonists has been attributed to TLR2. We raised monoclonal antibodies (mAbs) toward the murine TLR2 extracellular domain (mT2ECD) in order to analyze mu...     »
Journal title abbreviation:
Immunol Lett
Year:
2005
Journal volume:
98
Journal issue:
2
Pages contribution:
200-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.imlet.2004.11.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15860219
Print-ISSN:
0165-2478
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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