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Titel:

Role of endocytosis in cellular uptake of sex steroids.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hammes, A; Andreassen, TK; Spoelgen, R; Raila, J; Hübner, N; Schulz, H; Metzger, J; Schweigert, FJ; Luppa, PB; Nykjaer, A; Willnow, TE
Abstract:
Androgens and estrogens are transported bound to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex steroids inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. In line with this function, lack of receptor expression in megal...     »
Zeitschriftentitel:
Cell
Jahr:
2005
Band / Volume:
122
Heft / Issue:
5
Seitenangaben Beitrag:
751-62
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cell.2005.06.032
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16143106
Print-ISSN:
0092-8674
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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