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Title:

Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains.

Document type:
Journal Article
Author(s):
Eisensamer, B; Uhr, M; Meyr, S; Gimpl, G; Deiml, T; Rammes, G; Lambert, JJ; Zieglgänsberger, W; Holsboer, F; Rupprecht, R
Abstract:
Despite different chemical structure and pharmacodynamic signaling pathways, a variety of antidepressants and antipsychotics inhibit ion fluxes through 5-HT3 receptors in a noncompetitive manner with the exception of the known competitive antagonists mirtazapine and clozapine. To further investigate the mechanisms underlying the noncompetitive inhibition of the serotonin-evoked cation current, we quantified the concentrations of different types of antidepressants and antipsychotics in fractions...     »
Journal title abbreviation:
J Neurosci
Year:
2005
Journal volume:
25
Journal issue:
44
Pages contribution:
10198-206
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.2460-05.2005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16267227
Print-ISSN:
0270-6474
TUM Institution:
Klinik für Anästhesiologie (DHM)
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