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Titel:

Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization.

Dokumenttyp:
Journal Article
Autor(en):
Deiml, T; Haseneder, R; Zieglgänsberger, W; Rammes, G; Eisensamer, B; Rupprecht, R; Hapfelmeier, G
Abstract:
The convulsant effects of alpha-thujone, the psychotropic component of absinthe, were attributed to inhibitory actions at the GABAA receptor. Here, we investigated for the first time the 5-HT3 receptor as a potential site of the psychotropic actions of alpha-thujone. This cation permeable ligand-gated ion channel shows considerable homology to the GABAA receptor. We previously demonstrated that in homomeric assemblies of cloned human 5-HT,A receptor subunits. the endogenous agonist 5-HT induced...     »
Zeitschriftentitel:
Neuropharmacology
Jahr:
2004
Band / Volume:
46
Heft / Issue:
2
Seitenangaben Beitrag:
192-201
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15002407
Print-ISSN:
0028-3908
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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