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Titel:

[Effects of mechanical strain on human osteoblastic precursor cells in type I collagen matrices]

Dokumenttyp:
Journal Article
Autor(en):
Ignatius, A; Blessing, H; Liedert, A; Kaspar, D; Kreja, L; Friemert, B; Claes, L
Abstract:
BACKGROUND: The aim of the present study was to investigate the effect of mechanical strain on human osteoblastic precursor cells in a three-dimensional scaffold. METHODS: Osteoblastic precursor cells were seeded in a collagen type I gel and mechanically stretched by daily application of cyclic uniaxial strain. The expression of histone H4, core binding factor 1, alkaline phosphatase, osteopontin, osteocalcin, and collagen type I was investigated by analysing the mRNA. Cell and matrix orientatio...     »
Zeitschriftentitel:
Orthopade
Jahr:
2004
Band / Volume:
33
Heft / Issue:
12
Seitenangaben Beitrag:
1386-93
Volltext / DOI:
doi:10.1007/s00132-004-0735-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15578256
Print-ISSN:
0085-4530
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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